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Immunotherapy of cancer with immunomodulatory agents is achieving significant efficacy in an important fraction of patients. The stimulatory inducible receptor of T and NK lymphocytes known as CD137 or 4-1BB is being stimulated with agonist antibodies to enhance antitumor immunity in clinical trials. In addition, the intracellular signaling domain of CD137 is crucial as a component of Anti-CD137 antibodies are readily available from several suppliers. CD137 is a reported synonym of the human protein 'TNF receptor superfamily member 9', encoded by the gene TNFRSF9. The full protein is reported to be 255 amino acid residues in length. Jun 3, 2020 2a, CD137+ Vγ9Vδ2-T cells expressed higher levels of activation markers (CD25 , CD69 and NKG2D) and cell death-related receptor ligands Jan 15, 2010 At day 3 or 4 of culture, cells were harvested, stained with cell surface markers, and analyzed by flow cytometry.
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Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities. CD Markers - CD13. Granulocytes (most, but low levels in newbornss, Mod Pathol 1993;6:414), interdigitating dendritic cells, large granular lymphocytes (some), macrophages, mast cells, monocytes, myelomonocytes and osteoclasts 2016-03-18 · TMEM26, CD137, and TBX1 were identified as beige adipocyte markers by Wu and coworkers , but other labs have had mixed success in validating these markers [9, 10]. Our data indicate that TBX1 may have some utility as a marker to discriminate beige and white adipocytes in vitro , or if the assay is performed on the adipocyte fraction from white adipose tissue. CD137 is a 39 kD transmembrane protein also known as 4-1BB.
MeSH: Antigens, CD19 - Finto
As a costimulatory molecule it is involved in the activation and survival of CD4+ and CD8+ T cells, and NK cells. CD137 has been described to be a suitable marker for antigen-specific activation of human CD8+ T cells, as CD137 (ILA/4-1BB) is a member of the TNF receptor family and was identified in screens for receptors expressed on activated lymphocytes. 9 – 11 CD137 is expressed by activated lymphocytes and monocytes and expression in primary cells is strictly activation dependent. 12 Soluble forms of CD137 are generated by differential splicing and are present at enhanced concentrations in sera of patients with rheumatoid arthritis.
Literature references 2005- Immunotechnology
CD137 (TNFSFR9) was originally identified as a molecule induced on the surface of activated mouse and human CD4+ and CD8+ T cells, with its expression undetectable on non-activated T cells. It is also found on both NK and dendritic cells.
The Mtb-speciﬁc CD137+CD4+ T cells were mainly identiﬁed as having an effector memory phenotype. In conclusion, CD137 is a useful marker that can be
CD137 has been described to be a suitable marker for antigen-specific activation of human CD8+ T cells, as CD137 is not expressed on resting CD8+ T cells and its expression is reliably induced after 24 hours of stimulation.1The CliniMACS CD137 Product Line consists of murine anti-CD137 monoclonal antibodies conjugated to biotin.One vial contains 7.5 mL sterile, non-pyrogenic solution.The
CD137 (ILA/4-1BB) is a member of the TNF receptor family and was identified in screens for receptors expressed on activated lymphocytes. 9 – 11 CD137 is expressed by activated lymphocytes and monocytes and expression in primary cells is strictly activation dependent. 12 Soluble forms of CD137 are generated by differential splicing and are present at enhanced concentrations in sera of
2016-02-01 · CD137 is expressed by activated, but not resting, T cells and has been labelled as an activation marker and used to identify antigen-specific CD4 and CD8 T cells from naive and memory pools , , .
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Feature Type. protein coding Tnfrsf9 interacts with 173 markers (Mir18, Mir19b-1, Mir19b-2, ) View All. On lymphocytes, the presence of CD137 appears to be a marker for tumor reactivity. Activation of CD137 signaling can stimulate both cytotoxic T cell and NK cell Oct 24, 2017 The identification and study of antigen-specific CD4 T cells, both in peripheral blood and in tissues, is key for a broad range of immunological Detection of Human 4-1BB/TNFRSF9/CD137 antibody by Western Blot. Quadrant markers were set based on control antibody staining (Catalog # MAB1050). Western Blotting Image 1: 4-1BB/CD137/TNFRSF9 (E6Z7F) XP. Western blot analysis of extracts from primary human CD8+ T cells, treated with anti-CD3 and Mar 12, 2016 CD137(4-1BB) costimulation and adoptive T cell therapy strongly chimeric antigen receptors recognizing the B cell marker CD19 [3–5].
Introduction Tuberculosis (TB), which is caused by Mycobacterium
Detection and isolation of viable alloreactive T cells at the single-cell level requires a cell surface marker induced specifically upon T cell receptor activation. In this study, a member of the tumour necrosis factor receptor (TNFR)-family, CD137 (4-1BB) was investigated for its potential to identify the total pool of circulating alloreactive T
T cell Activation Marker (CD69, CD137, CD27, TRAP/CD40L, CD134) Antibody Panel - Human ab254024 contains multiple trial-sized versions of anti-human antibody clones against CD69, CD137, CD27, TRAP/CD40L, CD134, specifically selected for high performance in various applications. This panel contains 5 recombinant rabbit monoclonal antibodies against
Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities.
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2020-03-12 · For CD137 domain mapping, full-length CD137 ECD (aa 24–186), CRD 1-2 (aa 24–86), or CRD 3-4 (aa 87–186) expressed as fusions with mouse IgG2a-Fc were captured on anti–mouse-Fc Octet tips (ForteBio, catalog 18-5089). Loaded sensors were incubated with 100 nM of each antibody, and binding response was measured. 2019-11-08 · CD137 was originally discovered in 1989 and reported as a cell surface protein mainly located on activated T cells .
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Fur-ther, 6 times as many monocytes inﬁltrated CD137-express-ing cell spheroids than control spheroids. CD137 up-regulation as a surrogate marker for specifically activated CD8 + T cells in vitro and ex vivo. The activation threshold for several markers of response was compared in responding T-cell clones (A), T-cell lines (B), or memory T cells directly ex vivo (C).